PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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PEG3-I
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Tetrahydro-2-[[(3E)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-buten-1-yl]oxy]-2H-pyran
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0 ImagesCat. No.: HY-W614686CAS No.: 313342-78-8
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tert-Butyl 4-(2-aminoethyl)-3-oxopiperazine-1-carboxylate
0 ImagesCat. No.: HY-W102038CAS No.: 234108-58-8
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Tert-butyl (2-aminospiro[3.5]nonan-7-yl)(methyl)carbamate
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2-(Hydroxymethyl)cyclopropanecarbonitrile
0 ImagesCat. No.: HY-W563272CAS No.: 30491-95-3
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But-3-yn-1-yl methanesulfonate
0 ImagesCat. No.: HY-W259141CAS No.: 72486-09-0
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tert-Butyl (3-(chlorosulfonyl)propyl)carbamate
0 ImagesCat. No.: HY-W616788CAS No.: 1196153-59-9
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2-(2,6-Dimethylpiperazin-1-yl)ethan-1-amine
0 ImagesCat. No.: HY-W840623CAS No.: 468745-67-7
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[1,1'-Bi(cyclohexane)]-4,4'-diol
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0 ImagesCat. No.: HY-W009813CAS No.: 20601-38-1
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Tert-butyl n-methyl-N-[2-(piperidin-4-yl)ethyl]carbamate
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0 ImagesCat. No.: HY-W198256CAS No.: 171049-32-4
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BnO-PEG4-CH2COOH
0 ImagesCat. No.: HY-W348324CAS No.: 86259-56-5
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PEG4-NH-Cbz
0 ImagesCat. No.: HY-W574465CAS No.: 206265-31-8
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Methyl-Bn-PEG3-OH
0 ImagesCat. No.: HY-W613966CAS No.: 138471-93-9
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Methyl 3-{[(tert-butoxy)carbonyl]amino}cyclobutane-1-carboxylate
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0 ImagesCat. No.: HY-W057279CAS No.: 1234616-81-9
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Icosane-1,20-diol
0 ImagesSynonyms: 1,20-Eicosanediol
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Methyl benzenesulfonic acid-PEG3-O-NO2
0 ImagesCat. No.: HY-W140442CAS No.: 1973503-48-8
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tert-Butyl (11-bromoundecyl)carbamate
0 ImagesCat. No.: HY-W259180CAS No.: 463930-53-2
